Kelch Like Protein 8 (KLHL8)

By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2000) cloned KLHL8, which they designated KIAA1378. The mRNA contains a repetitive element in its 3-prime UTR, and the deduced 451-amino acid protein shares 36% identity with the actin-binding protein MAYVEN (KLHL2). RT-PCR ELISA detected highest expression in adult brain, liver, skeletal muscle, kidney, and ovary, and in several specific brain regions, predominantly amygdala and thalamus. Moderate expression was detected in all other adult and fetal tissues examined.Hartz (2008) mapped the KLHL8 gene to chromosome 4q22.1 based on an alignment of the KLHL8 sequence with the genomic sequence (build 36.1).