Kelch Repeat And BTB Domain Containing Protein 3 (KBTBD3)

KBTBD3 is well expressed, 0.8 times the average gene in this release. KBTBD3 contains 7 different gt-ag introns. Transcription produces 9 different mRNAs, 7 alternatively spliced variants and 2 unspliced forms. There are 2 probable alternative promotors, 4 non overlapping alternative last exons and 6 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 3""" end, presence or absence of 2 cassette exons. 390 bp of this gene are antisense to spliced gene AASDHPPT, raising the possibility of regulated alternate expression. Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified. This sequence motif represents one beta-sheet blade, and several of these repeats can associate to form a beta-propeller.