Keratin Associated Protein 1-3 (KRTAP1-3)

KRTAP1-3 is a member of the keratin-associated protein (KAP) family.KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21.The deduced 167-amino acid protein has a calculated molecular mass of 17.1 kD. KAP1.3 is classified as a high sulfur protein owing to a cysteine content of 25.7 mol %. It contains 2 unique motifs conserved among KAP1 family members, several characteristic pentapeptide repeats, and a 20-amino acid subdomain that was conserved among KAP1 family members in all species examined.