Keratin Associated Protein 5-1 (KRTAP5-1)

The IFAP group of keratin proteins comprises several families, with most proteins containing a large number of cysteine residues. Genes encoding one of these families, known as the ultrahigh-sulfur keratin (UHSK) proteins because they contain more than 30% cysteine residues, were isolated and their site of expression mapped to human hair and wool cuticle by tissue in situ hybridization. With the probe used, in situ hybridization pointed to localization in 2 regions of chromosome 11: the distal part of 11p15, most likely 11p15.5, and the distal part of 11q13, most likely 11q13.5. A probe from the 3-prime noncoding region of KRN1 mapped to 11q13.5. The sequence that mapped to 11p15.5 was termed KRN1-like.