Keratin Associated Protein 6-1 (KRTAP6-1)

KRTAP6-1 is a member of the keratin-associated protein (KAP) family. Hair is a structure that is unique to mammals. It plays an important role in the retention of heat, as well as sexual dimorphism, attraction of mates and protection of skin. The major components of hair are α-keratins and keratinassociated proteins, each of which are encoded by multigene families. Hair keratins form an intermediate filament network, which is embedded in an interfilamentous matrix consisting of KRTAPs. KRTAPS comprise three major groups, which are essential for the formation of rigid and resistant hair shafts through disulfide bond cross-linking or hydrophobic interactions with keratins. These groups are designated high Cysteine, which includes subfamilies 1, 2, 3, 10, 12, 16, 29 and 31, ultrahigh Cysteine, including subfamilies 4, 5, 9, 17, 28, 30, 32 and 33, and high glycine-tyrosine (HGT), which includes subfamilies 6, 7, 8, 19, 20 and 21.