Keratinocyte Associated Protein 1 (KRTCAP1)

PERP was downregulated in mammary carcinoma cell lines compared with nonmalignant mammary epithelium cell lines, in pancreas cell lines derived from metastases compared with a primary tumor cell line, and in several tumor tissues compared with normal tissues.PERP was downregulated in the metastasizing cell line. The deduced PERP protein contains 193 amino acids and has 4 transmembrane domains, 2 extracellular domains, and 3 cytoplasmic domains. Northern blot analysis using a multiple tissue array detected PERP expression in all adult and fetal tissues tested except peripheral blood leukocytes. Highest expression was in esophagus and trachea.