Kruppel Like Factor 12 (KLF12)

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. Kruppel Like Factor 12 is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.The deduced 402-amino acid protein contains 3 Gli-Kruppel C2H2-type zinc fingers and a prototypic H/C knuckle characteristic of the Drosophila Kruppel gene family. It also has a serine- and threonine-rich domain and a PVDLS repressor motif.