Kruppel Like Factor 3, Basic (KLF3)

The Krüppel-like family of transcription factors (Klfs),have been extensively studied for their roles in cell proliferation, differentiation and survival, especially in the context of cancer . All KLF family members are characterised by their three Cys2 His2 zinc fingers located at the C-terminus, separated by a highly conserved H/C link, DNA binding studies demonstrated that the KLFs have similar affinities for different GC-rich sites, or sites with CACCC homology, and can compete with each other for the occupation of such sites.The human and mouse KLF3 proteins contain 345 and 344 amino acids, respectively. Both have a characteristic zinc finger domain, but lack the N-terminal buttonhead box found in related SP transcription factors.