Lethal-3-Malignant Brain Tumor Like Protein 1 (L3MBTL1)

L3MBTL encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.One variant, L3MBT-I, encodes a deduced 772-amino acid protein. The other, L3MBT-II, has a 118-bp insertion and encodes a deduced 738-amino acid protein that is truncated at the C terminus. Both isoforms contain 3 central mbt repeats, followed by a C2HC zinc finger and a 60-amino acid SPM domain .