Lethal Giant Larvae Homolog 2 (LLGL2)

LLGL2 is a cortical cytoskeleton protein that is a part of a larger complex of proteins. The complex, which consists of LGN, PKC ι and PAR-6β, may play a role in ensuring the correct organization and orientation of bipolar spindles for normal cell division and for the initial phase of the establishment of epithelial cell polarity. In Drosophila melanogaster, LLGL2 is required in follicle cells for the differentiation of both stalk cells and posterior follicle cells. In humans, LLGL2 may be involved in cell proliferation control and tumorigenesis. Phosphorylation of LLGL2 is induced during cell polarization and may contribute to the segregation of LLGL2 from the PKC ι and PAR-6β complex. Overexpression of LLGL2 is thought to inhibit tight junction formation in cells. LLGL2 is expressed in the cytoplasm and localizes to the perinuclear structure of the cell.