Lymphoblastic Leukemia Derived Sequence 1 (LYL1)

On chromosome 19, the translocation occurred within a previously uncharacterized transcriptional unit for which Cleary et al. (1988) proposed the designation LYL1. An RNA of about 1.5 kb was transcribed from this gene in a wide variety of hematolymphoid cell lines. The t(7;19) resulted in truncation of the LYL1 gene and production of abnormal-sized RNAs, suggesting a role for LYL1 in the pathogenesis of this leukemia. By fluorescence in situ hybridization, Trask et al. (1993) assigned the LYL1 gene to 19p13.2-p13.1. Kuo et al. (1991) mapped the mouse Lyl-1 gene to chromosome 8, thereby defining a new region of homology of synteny with human 19p. The mapping was achieved in an interspecific backcross using a RFLP. The predicted mouse Lyl-1 protein was 78% identical to human LYL1.