MU-2/AP1M2 Domain Containing, Death Inducing Protein (MUDENG)

MUDENG is composed of 490 amino acids that contain the adaptin domain found in the mu2 subunit of APs related to clathrin-mediated endocytosis, is able to induce cell death by itself. Ectopic expression of MUDENG induced cell death in Jurkat T cells and HeLa cells. When MUDENG expression was evaluated by immnuohistochemical staining, it was found in most tissues, including the intestine and testis. MUDENG appears to be evolutionary conserved from mammals to amphibians, suggesting that it may have a common role in cell death. MUDENG is likely to play an important role in cell death in various tissues.