Melanoma Antigen Family B16 (MAGEB16)

By searching databases for sequences similar to MAGED2, Chomez et al. (2001) identified MAGEB16. The deduced protein contains the characteristic MAGE domain of about 200 amino acids. RT-PCR detected MAGEB16 expression in testis, but not in other normal tissues examined.By genomic sequence analysis, Chomez et al. (2001) mapped the MAGEB gene cluster to chromosome Xp22.2-p21.2.By database searching with the sequence of MAGEA10 as query, Lucas et al. (1999) identified a distantly related but homologous gene, MAGED2, which they designated MAGED. The deduced 606-amino acid protein contains a segment in its central region that is homologous to the 200-amino acid MAGE segment at the C terminus of other MAGE proteins.