Melanoma Antigen Family H1 (MAGEH1)

The deduced 219-amino acid protein contains a central conserved MAGE domain, but it differs from other MAGE proteins in its N and C termini. MAGEH1 was expressed at various levels in all normal tissues examined.Mageh1 was expressed as a cytoplasmic protein in a rat neural precursor cell line.The intracellular domain of nerve growth factor receptor (NGFR) interacted with necdin (NDN) and Mageh1 in rodent neural tissue, and the interaction was enhanced by ligand stimulation. Rat neural precursor cells transfected with necdin or Mageh1 exhibited accelerated differentiation in response to NGF.