Melanoma Derived Leucine Zipper Extra Nuclear Factor (MLZE)

Melanoma-derived leucine zipper extranuclear factor (MLZE) was originally isolated from a human melanoma cell line as a marker of melanoma progression . It was mapped to chromosome 8q24.1–q24.2, and its mouse homologue, Mlze, was mapped to the syntenic region in Band D1 of chromosome 15 (15D1).The human gene PRO2521 is renamed Gasdermin B; a mouse GSDMB homologue has not yet been found. Mlze, located on mouse chromosome 15, is renamed Gasdermin C1, and its human homologue located centromeric to BM-009  on chromosome 8q24.1 is renamed GSDMC. Finally, human GSDMDC1 and its mouse counterpart, Gsdmdc1, are renamed human Gasdermin D  and mouse Gasdermin D, respectively. In the phylogenetic tree in Fig. 1, the former name of each gene is shown in parentheses.