Metastasis Associated In Colon Cancer 1 (MACC1)

MACC1 is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (HGFR, or MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival.The deduced 852-amino acid has an SH3 domain, a proline-rich motif for binding SH3 domain-containing proteins, additional binding motifs for SH2 and SH3 domain-containing proteins, EPS15 homology domains, clathrin and retinoblastoma protein (RB1) interaction domains, and putative tyrosine phosphorylation sites. It shares about 44% identity with SH3BP4, and putative orthologs were identified in chicken, mouse, rat, dog, and chimp.