Neuroblastoma Breakpoint Family, Member 1 (NBPF1)

The NBPF gene family, of which NBPF1 is the founding member, consists of 22 genes and pseudogenes that arose by gene duplication. NBPF genes contain numerous low-copy repetitive elements and show high intergenic and intragenic sequence identity in coding and noncoding regions.The transcript contains repetitive elements in its 3-prime UTR, and the deduced protein contains 901 amino acids. RT-PCR ELISA detected high expression in all tissues examined except for low expression in kidney.In silico and RT-PCR analysis indicated ubiquitous expression of a group of NBPF genes, including NBPF1. Fluorescence- or epitope-tagged NBPF1 expressed in breast carcinoma cells showed reticulate cytoplasmic staining.