Nuclear Receptor Coactivator 7 (NCOA7)

NCOA7 encodes a 942-amino acid protein, which the authors called ERAP140 (estrogen receptor-associated protein of 140 kD). Northern blot analysis revealed an approximately 5.5-kb transcript in all tumor lines examined, including ESR-positive and ESR-negative breast cancer cell lines and HeLa cells. Northern blot analysis of multiple human tissues revealed highest expression in brain, with lower expression in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord, and pancreas. In situ hybridization in mouse tissues demonstrated exclusive expression in neurons in brain and significant expression in the cortex but not in the medulla in kidney.NCOA7 did not bind to RXRA in the presence or absence of ligand. NCOA7 can enhance the transcriptional activity of the nuclear receptors with which it interacts.