Olfactomedin 1 (OLFM1)

Noelin is a protein shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene.One of the sequences was found to encode a deduced 135-amino acid protein, which the authors termed AMY, that shares 96% sequence identity with a rat neuronal olfactomedin-related ER localized protein. Weaker expression was detected in 2 other neuroblastoma cell lines, but was not found in any other human tissues tested. The authors suggested that AMY may have an essential role in nerve tissue.