Olfactomedin Like Protein 1 (OLFML1)

The human olfactomedin-like 1 (OLFML1) gene encodes a secreted glycoprotein belonging to subfamily VII on a phylogenetic tree and is located on chromosome 11p15.4.The OLFML1 gene comprises of 3 exon and spans 25.8 kb. It encodes moderately conserved protein with a length of 402 amino acids also known as ONT2 in mice. Human Olfml1 protein shows 90% and 57% identities with mouse and zebrafish proteins, respectively. The human OLFML1 gene was highly expressed in small intestine, liver, lung, heart and spleen and was not expressed in brain. Available data suggest that OLFML1 protein enhanced human cancer cell proliferation in vitro via accelerating the entry into S phase.