Ovarian Cancer Immuno Reactive Antigen Domain Containing Protein 2 (OCIAD2)

OCIAD2 is highly expressed in adenocarcinoma mixed subtype with bronchioloalveolar carcinoma component and is associated with better prognosis. TncRNA, OCIAD2, ANXA2, TMED4 and LGALS4 were expressed at significantly higher levels in invasive adenocarcinoma mixed subtype with BAC than in BAC.Only the OCIAD2 gene showed significantly higher expression in the tumor cells of invasive adenocarcinoma mixed subtype with BAC than in BAC. The patients with OCIAD2 expression showed a better clinical outcome than those without OCIAD2 expression, and OCIAD2 expression showed an inverse correlation with lymphatic invasion, blood vessel invasion and lymph node metastasis. OCIAD2 begins to express at the progression from in situ to invasive carcinoma, and is associated with the favorable prognosis of adenocarcinoma mixed subtype with BAC component.