P Antigen Family, Member 4 (PAGE4)

PAGE4 is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer, but is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens.Sensitivity and specificity of the assay were 90% and 77%, respectively, and positive and negative predictive values were 74% and 91%, respectively. Prostate volume and presence of prostate cancer did not appear to alter the marker levels.