Plexin Domain Containing Protein 2 (PLXDC2)

While searching databases for the mouse Plxdc1 ortholog, Carson-Walter et al. (2001) identified Plxdc2, which they called Tem7r. They subsequently identified the human PLXDC2 sequence, which encodes a predicted 529-amino acid transmembrane protein that shares 91% amino acid identity with mouse Plxdc2.TEM7R was expressed clearly in the endothelial cells of the tumor stroma but not in the endothelial cells of normal colonic tissue. Using in situ hybridization to assay expression in various adult mouse tissues, Carson-Walter et al. (2001) detected Tem7r expression at high levels not only in tumor endothelium but also in vessels of some normal tissues, with highest expression in muscle and lung.