Polyhomeotic Like Protein 1 (PHC1)

PHC1 is a homolog of the Drosophila polyhomeotic gene, which is a member of the Polycomb group of genes. The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMH1. The gene product, the EDR2 protein, and the Drosophila polyhomeotic protein share 2 highly conserved domains, named homology domains I and II. These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this gene and the EDR2 protein.The amino acid sequences of HPH1 and Rae28 are 95% identical. HPH1 shares homology with HPH2 and Ph in the zinc finger domain and in 2 regions designated homology domains I and II. HPH1 was expressed as 4.4- and 6-kb transcripts in several tissues, with the highest expression in thymus, testis, and ovary.