Proteasome Assembly Chaperone 2 (PSMG2)

CLAST3 expression increased in human and mouse B cells upon activation. In synchronized mouse fibroblasts, Clast3 expression was low in G1-arrested cells and increased during S and G2-M phases.The deduced 264-amino acid protein contains 2 N-glycosylation sites, 3 N-myristoylation sites, and several phosphorylation sites. Northern blot analysis detected a 1.7-kb HCCA3 transcript in all tissues examined. Expression was high in lung, brain, and colon, moderate in muscle, stomach, spleen, and heart, and weak in small intestine, pancreas, and liver. Elevated HCCA3 expression in hepatocellular carcinoma was associated with tumor invasiveness and metastasis, but not with tumor size, degree of differentiation, or other parameters.