RAB, Member Of RAS Oncogene Family Like Protein 2A (RABL2A)

RABL2A is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Two alternatively spliced transcript variants have been identified, both encoding the same protein. RABL2A and RABL2B proteins have 228 amino acids each and differ from each other by 3 conserved amino acid changes.The RABL2 proteins also lack the C-terminal cysteine-rich domain important for the binding of RABs to vesicle membranes, and are therefore likely to have a different function from other RAB proteins.