RAB30, Member RAS Oncogene Family (RAB30)

Chen et al. (1996) isolated a cDNA encoding RAB30, a small GTP-binding protein of the RAB family, from a human melanocyte cDNA library and from melanoma cells. The deduced 203-amino acid RAB30 protein shares minimal homology with previously documented GTPases. Northern blot analysis detected RAB30 transcripts ranging from 1.7 to 11 kb in most tissues tested.By somatic cell hybrid analysis, Chen et al. (1996) mapped the RAB30 gene to chromosome 11. Scott (2001) localized the RAB30 gene to 11q12-q14 based on sequence similarity between the RAB30 sequence and chromosome 11 clones.