RAB3D, Member RAS Oncogene Family (RAB3D)

Sequence analysis of a partial 2.0-kb cDNA indicated an open reading frame encoding 80 amino acids, with small stretches of Alu repeat sequences in the 3-prime untranslated region. The authors found that GOV is also highly expressed in recurrent glioma, colon tumor metastatic to brain, breast tumors, prostate tumors, and several tumor cell lines. It is also highly expressed in some normal tissues such as thyroid, stomach, adrenal cortex, small intestine, and pancreas. GOV expression is localized to the frontal lobe, occipital lobe and the cerebellum in the normal brain, and is expressed 28-fold higher in fetal brain (20 weeks) than in adult brain.The deduced 219-amino acid sequence shows highest homology to the RAB3 subfamily of low molecular mass GTP-binding proteins.