Ras Homolog Gene Family, Member Q (RHOQ)

TC10 is a member of the RAS superfamily of small GTP-binding proteins involved in insulin-stimulated glucose uptake.TC10 is a member of the Rho group of RAS-related genes, encoding proteins thought to play a role in the control of microfilament assembly. TC10 exhibits approximately 60% nucleotide sequence homology to TC25 and to other RHO genes. Drivas et al. (1990) detected TC10 expression in human 293 cells and mouse NIH 3T3 cells, but not in HeLa or Jurkat T-cell lines.The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation