Ras Like Family 10, Member B (RASL10B)

RASL10B has a molecular mass of 23.2 kD and contains 5 guanine nucleotide binding sites and a C-terminal CAAX box. RT-PCR analysis of human tissues detected strong expression in brain, pancreas, and prostate, with moderate expression in lung and thymus, and low expression in liver and spleen. Immunofluorescence localized RASL10B to the cytoplasm in COS-7 cells. RASL10B mRNA was downregulated in human breast cancer cell lines compared to a normal human breast cell line.RRP17 interacted with the C-terminal region of CAPS1 (CADPS), a regulator of large dense-core vesicle secretion. Primary rat neonatal cardiomyocytes infected with recombinant adenovirus expressing RRP17 secreted 2.5- and 3.5-fold more atrial natriuretic peptide (ANP) compared to uninfected or lacZ-expressing cardiomyocytes.