Ras/RAD And Gem Like GTP Binding Protein 1 (REM1)

REM1 contains 4 GTP-binding domains unique to its family, extended N- and C-terminal domains beyond the RAS-related domain, a putative calmodulin-binding domain, and a conserved C-terminal motif. REM1 shares 43.8%, 44.1%, and 87.9% similarity to RAD, GEM and murine Rem1, respectively. Northern blot analysis detected highest expression in uterus and heart, with lower expression in skeletal muscle, pancreas, spleen, thymus, prostate, testis, small intestine, colon and lymph node. In situ hybridization analysis revealed high expression in endothelial linings of heart and uterus, and in secretory tissues including islets of Langerhans, breast lobule/duct epithelium, uterine endometrial gland epithelium, colon mucosa, and acinar cells of pancreas and prostate.