Ras Responsive Element Binding Protein 1 (RREB1)

RREB1 is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in Ras/Raf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene.RREB1, a zinc finger transcription factor, was shown to bind specifically to the distal RAS-responsive element (RRE) in the calcitonin gene promoter and to augment the RAS/RAF-mediated transcriptional response of that promoter. Thus, they concluded that it may be involved in RAS/RAF-mediated cell differentiation.