Rho Family GTPase 2 (RND2)

Rnd2 is a small (~21 kDa) signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases.. It is encoded by the gene RND2.It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors .This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking.The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1.RHO7 was identified initially as a homolog to the RHO family of GTP-binding proteins by a database search using deduced amino acid sequences from predicted exons. The gene was found to be highly similar to the mouse EST homolog, with more than 90% identity between the 2 nucleotide sequences.