Rhomboid Domain Containing Protein 2 (RHBDD2)

RHBDD2 over-expression behaves as an indicator of poor prognosis and may play a role facilitating breast cancer progression. Interestingly, specimens displaying RHBDD2 over-expression were predominantly advanced stage III breast carcinomas.RHBDD2 gene amplification was detected in 21% of 98 invasive breast carcinomas analyzed. Interestingly, siRNA-mediated silencing of RHBDD2 expression results in a decrease of MCF7 breast cancer cells proliferation compared with the corresponding controls. In addition, analysis of publicly available gene expression data showed a strong association between high RHBDD2 expression and decreased overall survival, relapse-free survival, and metastasis-free interval in patients with primary ER-negative breast carcinomas.