SAR1 Gene Homolog B (SAR1B)

SAR1B belongs to the Sar1-ADP ribosylation factor family of small GTPases,which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles.The deduced 198-amino acid SARA1 protein contains 4 highly conserved GTPase motifs. Northern blot analysis detected strong expression of a major transcript of 2.4 to 4.4 kb in all tissues examined. Smaller and larger variants were also detected in most tissues.SAR1B belongs to the Sar1-ADP-ribosylation factor family of small GTPases, which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles. The human SARA1B protein shares 99% amino acid identity with hamster Sar1. SARA1B is expressed in many tissues including small intestine, liver, muscle, and brain.