SH2B Adaptor Protein 1 (SH2B1)

SH2B1 encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described.The deduced 670-amino acid protein contains an SH2 domain in its C-terminal half. The rat Sh2b-alpha protein contains 757 amino acids and is identical to Sh2b-beta through the SH2 domain, but the proteins have different C termini.The deduced 682-amino acid protein differs from Sh2b-alpha and Sh2b-beta only in the C terminus. Northern blot analysis detected expression in all mouse tissues examined.