Salvador Homolog 1 (SAV1)

SAV1 is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.The deduced 383-amino acid protein has a predicted molecular mass of approximately 45 kD. It contains 2 WW domains, a region rich in prolines and glutamines, and a coiled-coil region, as well as a nuclear localization signal and 2 endoplasmic reticulum retention signals. The mouse Ww45 cDNA has a different 3-prime untranslated region and encodes a protein that shares 93% identity with human WW45. In human, highest expression was in pancreas, while in mouse, highest expression was in testis. Northern blot analysis of whole mouse embryos showed that embryonic expression of Ww45 first occurred at 7 days postcoitum.