Septin 10 (SEPT10)

Septins, such as SEPT10, are conserved GTP-binding proteins that function as dynamic, regulatable scaffolds for the recruitment of other proteins. They are involved in membrane dynamics, vesicle trafficking, apoptosis, and cytoskeleton remodeling, as well as infection, neurodegeneration, and neoplasia.The deduced 517-amino acid protein has a calculated molecular mass of 60 kD. SEPT10 shares approximately 70% amino acid identity with SEPT8 and SEPT6, and it contains an N-terminal ATP/GTP-binding motif conserved in the septin family and a C-terminal coiled-coil domain. SEPT10 expression was detected in most but not all tumor cell lines examined. SEPT10 expression was increased in mature dendritic cells compared with immature dendritic cells.