Septin 11 (SEPT11)

SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking.The deduced 429-amino acid protein has a unique N-terminal region followed by a conserved GTPase domain and a C-terminal domain. Northern blot analysis detected SEPT11 expression in all tissues examined except leukocytes, with transcripts of 6.5, 3.0, and 2.0 kb expressed in a tissue-specific manner. Western blot analysis detected SEPT11 at an apparent molecular mass of 48 kD in rat brain and in several mammalian cell lines, including human. Endogenous SEPT11 localized to short filaments in HeLa and COS-7 cells, and SEPT11 colocalized with microtubule or actin cytoskeletal elements in other cell lines in a cell type-dependent manner.