Septin 14 (SEPT14)

SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions .SEPT14 has a GTPase domain followed by a C-terminal coiled-coil domain characteristic of group II septins. SEPT14 shares highest identity (67%) with SEPT10. Northern blot analysis detected testis-specific expression of a 5.0-kb transcript. RT-PCR detected SEPT14 in testis and more weakly in fetal liver, tonsil, and thymus. Expression was not detected in testicular cancer or other normal or cancer cell lines. Fluorescence-tagged SEPT14 colocalized with SEPT9 to stress fibers in transfected Chinese hamster ovary (CHO) cells.