Septin 2 (SEPT2)

SEPT2 can hetero-oligomerize wth SEPT6 and SEPT7 to form filaments. SEPT2 interacted with SEPT6 through its C-terminal coiled-coil domain. Knockdown of SEPT2, SEPT6, and SEPT7 in causes actin stress fibers to disintegrate and cells to lose polarity. The NEDD5 cDNA encodes a predicted protein of 406 amino acids. The deduced peptide sequence contains conserved domains rich in basic residues, a motif of the GTPase superfamily. Different poly(A) sites account for generation of 2 transcripts. The major 3.5-kb transcript was expressed ubiquitously in all human tissues examined, and a 2.0-kb alternative transcript lacking any long AU-rich element in the 3-prime noncoding region was expressed abundantly only in testis, heart, and skeletal muscle.