Serine Incorporator 4 (SERINC4)

SERINC4, Belongs to the TDE1 family. TDE1 (for Tumor Differentially Expressed) following a screen of differentially expressed genes in cell lines derived from pre- or post-adematous testes of transgenic mice. The human homologue of the recently described TDE1/TMS family of proteins whose members have been identified in several species. Although a defined biochemical activity has yet to be assigned to TDE1/TMS family members, previous results point to the overexpression of family members in tumor cell lines or tissues. Expression of hTDE1 in Rat-1 transfectants had a significant effect on cell contact inhibition in vitro as judged by a focus formation assay. hTDE1 overexpression partially protects cells from serum starvation- and etoposide-induced apoptosis.