Serologically Defined Colon Cancer Antigen 10 (SDCCAG10)

PPIL2, PPIL6, and SDCCAG-10 are clearly divergent from the rest of the family in terms of in vitro activity.For PPIL2 and SDCCAG-10, both of which have been found associated with spliceosomal complexes, it may be that it is the non-active surface of the PPIase domain that performs the major function as in the cases of PPIH and PPIL1.The screening of cDNA expression libraries derived from human tumors with autologous antibody (SEREX) has proven to be a powerful method for defining the structure of tumor antigens recognized by the humoral immune system. In the present study, 48 distinct antigens (NY-CO-1-NY-CO-48) reactive with autologous IgG were identified by SEREX analysis in 4 patients with colon cancer.