T-Cell Leukemia/Lymphoma Protein 1A (TCL1A)

TCL1, is situated at 14q32.3 and is activated when it comes into juxtaposition with the TCRA locus with inversion; . Erikson et al.  showed that the TCRA locus is split between the proximal V gene and the more distal C gene by the breakpoint at 14q11.2 that creates of T-cell leukemia. Mathieu-Mahul et al.cloned a DNA fragment from 14q11 in a case of T-cell malignancy. Mengle-Gaw et al.  and Davey et al.  both studied chromosome rearrangements, inversions, or translocations, involving 14q in patients with ataxia-telangiectasia . These patients are prone to the development of lymphatic neoplasms in association with these abnormalities. Mengle-Gaw et al.  concluded that a single locus at chromosome band 14q32.1, located about 15-20 million basepairs centromeric to the IGH locus, is critical to the development of neoplasia.