TNF Receptor Associated Factor 5 (TRAF5)

Tumor necrosis factor (TNF) receptor-associated factors (TRAFs), such as TRAF5, are signal transducers for members of the TNF receptor superfamily . TRAF proteins are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs, a coiled-coil (leucine zipper) motif, and a homologous region in the C terminus that defines the TRAF family, the TRAF domain. The TRAF domain is involved in self-association and receptor binding.human cDNA has a 557-amino acid open reading frame that exhibits 80% identity to mouse TRAF5 at the amino acid level. Northern blot analysis revealed that human TRAF5 mRNA is expressed in all visceral organs. Western blotting revealed that the human protein is abundantly expressed in a human follicular dendritic cell line, and to a lesser degree in several tumor cell lines.