Ten-Eleven Translocation Methylcytosine Dioxygenase 3 (TET3)

TET3, play a role in the DNA methylation process.the deduced TET3 protein contains 1,660 amino acids and shares 2 C-terminal highly conserved domains, a cys-rich region and a 2OGFeDO homology domain, with TET1 and TET2. By real-time PCR analysis, they demonstrated that TET3, like TET2, is ubiquitously expressed with highest expression in hematopoietic cells, particularly of myeloid and monocytic lineage.TET3, like TET2, is ubiquitously expressed with highest expression in hematopoietic cells, particularly of myeloid and monocytic lineage.Tet1, Tet2, and Tet3, can also catalyze the conversion of 5-methylcytosine to 5-hydroxymethylcytosine. Tet1 has an important role in mouse embryonic stem cell maintenance through maintaining the expression of Nanog in embryonic stem cells.