Testis Expressed Protein 13A (TEX13A)

In a systematic search for genes expressed in mouse spermatogonia but not in somatic tissues, Wang et al. (2001) identified 25 genes, 19 of which were novel, that are expressed in only male germ cells. Of the 25 genes, 3 are Y-linked and 10 are X-linked, indicating that the X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis. One of the novel X-linked mouse genes, testis-expressed gene-13, encodes a 186-amino acid protein that has testis-specific expression.Wang et al. (2001) found that Tex13 has 2 human orthologs, TEX13A and TEX13B. Wang et al. (2001) sequenced a full-length TEX13A cDNA.By radiation hybrid analysis, Wang et al. (2001) mapped the TEX13A and TEX13B genes to the X chromosome.