Testis Specific Y Encoded Like Protein 4 (TSPYL4)

TSPYL4, Belongs to the nucleosome assembly protein (NAP) family. Mutation analysis was performed for the TSPYL and TSPYL4 genes in the linked region on chromosome 6q22. TSPYL4, was found 25 kb proximal to TSPYL, but direct sequencing of an affected individual identified no coding variants.TSPYL may play a role in development by altering regulation of specific developmental genes and contributing to region-specific chromatin remodeling. Several data sets within the Gene Expression Omnibus (GEO) illustrate that TSPYL is highly and almost exclusively expressed in the fetal brain. In addition, TSPYL has been shown to be negatively regulated in the hippocampus in a linear dose-dependent fashion by corticosteroids, sensitively negatively regulated by JNK2, and positively regulated by testosterone.