Tumor Protein D54 (TPD54)

Nourse et al. (1998) identified EST sequences with similarity to tumor protein D52. They cloned the corresponding cDNA, termed D54, from a breast carcinoma library. The longest cDNA predicted a 206-amino acid polypeptide with 56% and 51% identity to TPD52 and TPD52L1, respectively. Nourse et al. (1998) reported that some of the D54 clones that they isolated were alternatively spliced variants. Northern blot analysis and RT-PCR of rat tissues revealed that some splice variants of D54 were ubiquitously expressed, while others had a restricted expression pattern.Nourse et al. (1998) used isotopic in situ hybridization to map the TPD52L2 gene to human chromosome 20q13.2-q13.3, a region that is frequently amplified in breast and other cancers. This localization is independent of the map locations of TPD52 and TPD52L1.