Tumor Suppressor Candidate 1 (TUSC1)

The deduced 209-amino acid TUSC1 protein shares 79% sequence similarity with mouse Tusc1. Northern blot analysis detected 2.0-kb and 1.5-kb transcripts, most likely generated by alternative polyadenylation signals, in most tissues examined, with highest expression in testis, weak expression of the 2.0-kb transcript in muscle, and weak expression of the 1.5-kb transcript in colon, lung, and spleen. An additional 1.1-kb transcript was detected exclusively in testis.Using RT-PCR analysis, Shan et al. (2004) detected no TUSC1 transcripts in 3 nonsmall cell lung carcinoma cell lines with homozygous deletion of the 9p region and showed decreased TUSC1 expression in 3 other tumor cell lines